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Stroke of Youth: How Genetics Play Russian Roulette with Early-Onset Strokes

Unveiling the hidden genetic cards that tip the odds against young stroke survivors

Alain Suppini
3 min readNov 11, 2024
Illustration Adobe Stock

When Stroke Hits Young: The Silent Saboteur

Picture this: You’re in your 30s, juggling work deadlines, family, and fitness goals, when suddenly, your body shuts down. Early-onset ischemic stroke (EOS) isn’t just a health anomaly; it’s a life-altering event. Unlike its late-onset counterpart, EOS strikes before 60, often leaving victims blindsided. But what if the culprit isn’t lifestyle alone, but also hidden in your DNA?

Recent studies reveal the role of common genetic variants in EOS, providing new insights into this deadly puzzle. Let’s dive into the genetic lottery shaping your stroke risk.

The ABO Gene: A Blood Type Gamble

Your blood type isn’t just a handy fact for emergencies — it could be your genetic ticking clock. Research highlights the ABO gene as a major player in stroke risk. Specifically, subgroups A1 and O1 seem to act like opposing forces in this genetic game.

  • Blood group A1 raises the odds of EOS, acting like a stealthy saboteur in your bloodstream.

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Alain Suppini
Alain Suppini

Written by Alain Suppini

Anesthesiologist and Intensive Care Physician passionate about Holistic Medicine and Well-Being.

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